The Married…with Children star has quit acting because of her MS issues.

Christina Applegate has been quite open about her health issues, particularly after disclosing in 2021 that she had been given a multiple sclerosis diagnosis.

She has recently stated that she will be stepping away from the camera owing to her condition, and she commented on this during Variety’s TV FYC Fest on June 7.

The 51-year-old actress talked openly about her Hollywood Walk of Fame ceremony in November and how she invited her co-stars from her most recent role (Dead to Me), in which she co-starred with Linda Cardellini and Liz Feldman, as well as those from her earlier roles (Married… with Children’s Katey Sagal and David Faustino), to stand by her side.

She paused for a time before continuing, “There was no misunderstanding as to who I requested to speak, sort of my beginning and my…, my possibly end. To me, that was very important.”

The actress made a suggestion that Dead to Me might be her final on-screen appearance while she was present at the SAG Awards in February.

She expressed in her interview with Variety that she couldn’t have been happier with her final bow, saying, “This is what I had always dreamed of doing.”

For her work with Linda, Christina received three Primetime Emmy nominations and a Golden Globe nomination for the show’s last season, which aired in November.

“We don’t know what my future as an actress will be,” she said, adding that the Netflix show’s cast and crew made concessions for her after learning of her condition.

“How do I deal with it? How can I enter a set and make decisions regarding my physical needs and boundaries? Who will be as kind and understanding as this bunch of people was, I wonder.”

Christina opened up about witnessing herself suffer while filming and how it came over in the finished movie. Christina is also the mother of daughter Sadie Grace, 12, who she shares with husband Martyn LeNoble.

She admitted, “I could see the terrible pain I was in every day I was there, and I didn’t want to relive it.” “I had to take it in very little doses, but I still believe it’s a lovely work. I’m extremely appreciative that Liz saw my potential.”

She might not appear on TV as much, but she will keep giving amazing performances off-camera.

She was enthusiastic about her planned voice-over gigs, including one she called “one of the coolest things I’ve ever done,” her work as a producer, and her plans to launch a podcast with a buddy who also has MS.

The actress previously described her symptoms as insomnia, numbness, and tingling in her limbs, which are telltale signs of the neurological disorder, and the inability to walk without a walking stick, which she previously described as “now part of my new normal.”

The brain and spinal cord are affected by the disorder known as multiple sclerosis or MS. It usually manifests between the ages of 30 and 50, and women are more likely to experience it. Once diagnosed, it rarely proves fatal but remains debilitating for the rest of your life.